Pharmacological action of active ingredients
Diactral increases insulin secreation through insulin secretagogues or insulinomimetic action of Momordica charantia, Pterocarpus marsupium, Piper nigrum, Curcuma longa. helps to stimulation of skeletal muscle and peripheral cell glucose utilization, inhibition of intestinal glucose uptake, inhibition of adipocyte differentiation, suppression of key gluconeogenic enzymes, stimulation of key enzymes, HMP pathway and preservation of pancreatic islet cells and their functions
Effective hyperglycemic control crucible important to prevent the microvascular and macrovascular complications of DM.
Momordica charantia decrease hepatic, glucose production and prevent hyperglycemia. Pterocarpus marsupium helps to reduce the glucose absorption from the gastrointestinal tract and improve insulin and pro-insulin levels. Due to their ability to restore the function of pancreatic tissues by causing an increase in insulin output or inhibit the intestinal absorption of glucose or to the facilitation of metabolites in insulin dependent processes
Alpha-glucosidase inhibitory action retards carbohydrate digestion, an alternate means to reduce postprandial hyperglycemia. Due to prevent the degradation of complex carbohydrates into glucose, the carbohydrates will remain in the intestine. Salacia oblonga binds to intestinal enzymes alpha glucosidases that break down carbohydrate into glucose in body.
Azadirachta indica glycogenolytic effect due to epinephrine action was blocked.
Diactral increases hepatic and muscle glycogen content.
Momordica charantia, Pterocarpus marsupium enhance peripheral utilization of glucose.
Beta-cells destruction is common in DM.
Pterocarpus marsupium regenerates beta cells of pancreas to produce insulin naturally and save beta-cells and pancreas from deterioration by restricting load, and promoting unrestricted endogenous insulin action.
Dibetes mellitus affects peripheral and autonomic nerves, leading to various neurological complications.In diabetic condition there will be decreased utilization of glucose through glycolysis. As glucose is freely permeable to nerve tissue, there is accumulation of glucose in sciatic nerve which is metabolized, via the activated sorbitol pathway enzymes aldose reductase (AR) having high Km for glucose and sorbitol dehydrogenase (SDH), to sorbitol and fructose whose accumulation in the nerves is known to be implicated in the development of long-term diabetic complications.
Eugenia jambolina and Curcuma longa has neuroprotective action and protect from diabetic neuropathies.
Diabetic Renopathy is a frequent consequence of long-standing diabetes mellitus, which may lead to renal failure. Diactral effectively reduces the risk of diabetes nephropathy.
Curcuma longa, Eugenia jambolina, picrroriza kurroa reduce urinary protein excretion in glomerulopathies, and also attenuate progression to end stage renal disease.
Diactral effectively reduces the risk of diabetic retinopathy. An effective adjuvant to conventional OHAs where the resolution of retinopathy is enhanced, Diactral resolves, prevents and retards retinal and vitreal microaneurysms,and proliferative retinal changes.
Curcuma longa, with its antioxidant and anginogenic actions, inhibits Ca(2+) entry and protein kinase C activity, which help prevent diabetic retinopathy. Pterocarpus marsupium have aldose reductase inhibitory actions, and thus prevent acceleration of cataract formation in diabetics.
Diactral effectively reduces the risk factors of coronary arteries disease (CAD) by modulating lipid profile through its antihypercholesterolemic properties. In diabetes LDL and VLDL carry cholesterol to the peripheral tissues where it is deposited, whereas HDL transports cholestrol from peripheral tissues to the liver and thus aids its excretion. Increasese high level of HDL i.e. good cholesterol .Diactral reduces the level of free fatty acids and renormalizes lipid abnormilites associated with NIDDM.
Curcuma longa, Momordica charantia, Pterocarpus marsupium, Piper nigrum decreases serum level of bad cholesterols, free fatty acids and triglycerides.
Stress is an important factor, which influences the progression of DM and its complications.
Withania somnifera have potent adoptogenic action that helps control disease-associated stress. it stimulates the cell to produce proteins that help resist stress and enhance longevity.
Ref: Panossian, A., Adaptogens, Tonic Herbs for Fatigue and Stress, Alt Complement Ther, 2003;9(6):327-331
Diactral increases localized superoxide dismutase activity, which prevents oxidative damage (by formation of free radicals) to b-cells in islet of langerhans, and protects b-cells from destruction.
Diabetic endothelial dysfunction is associated with diabetic vasculopathy, and control of oxidative damage is crucial. Piper Nigrum, Trifala, Enicostemma littorale is a potent anti-oxidant propertiesprotection from oxidative damage in diabetic vasculopathy.
NUTRIENT BIOAVAILIBILTY ENHANCER
BioPerine is a standardized extract from the fruits of Piper nigrum L., contains 95% piperine which is very effective for both human and animals when used as food additives. Its termed as natural absorption of curcumin is limited due to its poor absorption of GI tract, therefore bioperine significantly improved the uptake of curcumin.
Nisar Ahmad et al./Asian Pacific Journal of Tropical Biomedicine (2012)S1945-S1953
Caesalpinia crista, an immunomodulator, enhance immunity and a general sense of well-being.
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